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Life Extension, SAMe, 400 mg, 60 enteric-coated vegetarian tablets Artichoke of enhanced absorption vitamin DDescription Our Best Seller SAMe, or S Adenosyl Methionine, benefits many critical metabolic functions in the body. This amazing compound helps maintain a stable mood and supports both joint and liver health. What Is SAMe? SAMe participates in many critical metabolic functions by donating methyl groups to other molecules. Methyl groups need to be transferred between compounds in the body to help with things like neurotransmitter signaling and protein