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Small molecules, as the phosphodiesterase-4 inhibitor apremilast, approved for the treatment of adults with moderate-to-severe plaque psoriasis and/or psoriatic arthritis, have demonstrated a broad anti-inflammatory activity, which may influence metabolism (17, 78)

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A meta-analysis of 29 studies of orlistat for weight loss in adult patients reported a weight loss of 2.59 kg and 2.89 kg at 6 months and 12 months, respectively [33,34]