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In turn, GSSG can again be reduced back to GSH with the help of nicotinamide adenine dinucleotide phosphate (NADPH) and glutathione reductase (GR), maintaining a redox cycle (GSH ↔ GSSG) (Figure 2)

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This pathway generates pentose sugar for synthesis of amino acid and nucleic acid and converts glucose to ribulose-5-phosphate via retrieving the carbon from the pentose phosphate shunt.78 Vitamin B2 (Riboflavin) plays an important role in many biologically important redox reactions such as energy producing, biosynthetic, detoxifying and electron scavenging pathways as a precursor of coenzyme flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) (9-10)